ISO 14607:2024 Annex C.3 and the document Docket No. 2004D-0124 from the U.S. Food and Drug Administration (FDA) describe fatigue tests on breast implants aimed at developing a Wöhler (S–N) curve. Unlike the fatigue tests under shear stress according to ISO 14607, the implants in the FDA guideline Docket No. 2004D-0124 are subjected to cyclic compressive loading. Sinusoidal load cycles with defined upper and lower loads are applied up to a run-out level of 6.5 million cycles. We offer this test together with static rupture tests according to ISO 14607:2007.